C-reactive Protein Human Fibrosarcoma by Treatment with Liposomes Containing Inhibition of Lung Metastases in Mice Bearing a Malignant

Recent studies suggest an immune modulator role for Creactive protein (CRP). We have tested the effect of CRP in a tumor system designed for study of métastases.Fibrosarcoma T241 was implanted on one hind foot of syngeneic C57BL/6 mice. After 17 days, the tumor-bearing feet were amputated, and i.v. therapy of liposomes containing CRP or control re agents was started. Examination of the lungs on Day 35 showed that CRPiliposome-treated animals had significantly fewer and smaller métastases as compared with those in the control groups. Moreover, 38% of the animals in the former groups were completely free of métastasesas compared with 0 to 2% of the controls. Significantly, enhanced survival was also noted in the CRP:liposome-treated group. CRP may have "biological response modifier" function of value in cancer therapy.